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Perimenopause Research in 2026

Good news and bad news
For those going through perimenopause in 2026, there is good news and bad news. The good news is awareness about perimenopause has exploded in the past several years. Those of us going through perimenopause are less likely to feel alone and our perimenopausal experiences are more likely to be validated today than they were 5 years ago. The bad news is that while there is greater awareness about perimenopause, research doesn’t yet provide answers to many questions about why certain symptoms arise and how to manage the most disruptive ones.

Some facts about perimenopause knowledge in 2026

  • Building new knowledge takes time. Most of the longitudinal studies about midlife women began in the 1990s.

  • Education about women’s health for both healthcare providers and women themselves is dependent on this research. This article explains the history.

  • Building a body of evidence about perimenopause will require replicating outcomes from studies before changes are made to how perimenopause is treated and this takes time.

  • This knowledge gap creates a vacuum and the vacuum often gets filled by people who go beyond the available data or select a specific outcome from one  study but ignore other similar studies that yield contradictory outcomes (often referred to as “cherry picking”).

  • It’s nearly impossible to be wise to all of this as there is a great deal of nuance in interpreting research. In this post we share some ways to be a wise consumer of research. We also offer Dr. Nanette Santoro’s article about ways to spot misinformation.

  • Below we explain specific research relevant to perimenopause. We also explain the Women’s Health Initiative although participants were postmenopausal.

Dive deeper on specific perimenopause research

Sleep Disruption

Research validates that sleep disruption can be separate from night sweats

Depressive symptoms

Research associates changes in levels of both estrogen and progesterone.

The Women’s Health Initiative (WHI)

A study that is often misunderstood.